US Patent # 6,653,327 titled “Cross-regulin composition of tumeric-derived tetrahydrocurcuminoids for skin lightening and protection against UVB rays” was granted to Sabinsa Corporation on November 25, 2003.

The patent describes a mixture of tetrahydrocurcuminoids which can be used for regulating random, intracellular protein cross-linking and to optimize cell electric potential. The composition can be orally, parenterally or topically administered to obtain the desired nutraceutical and cosmeceutical benefits.